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Other hand, in the duration of tooth chattering and threat posture were higher than those in the control group. No significant difference was observed between the leaded and unleaded gasoline.Table 3: Effect of chronic exposure to two types of gasoline vapour on the content of monoamines (g/g) in the hippocampus of male ratsParameter GROUP Control Leaded gasoline Unleaded gasoline Norepinephrine 0
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Ecules or to relative reduction in acetylcholinesterase-containing neurons, thus potentiating cholinergic effects. In the present study, no statistical differences were detected among the serotonin levels of the cerebral cortex in the three groups; the control, the leaded and the unleaded. However, in the hypothalamus, hippocampus, cerebellum, the serotonin level was lower in the groups exposed to
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D that volatile solvents such as benzene, a main constituent of gasoline fuel, seems to interact with the synthesis and catabolism of catecholamines and serotonin in the brain, which might explain the neurotoxic effects of these solvents [53]. In this regard, deficiencies of serotonin or other monoamine neurotransmitters such as dopamine and norepinephrine are linked with depression [54,55]. In re
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Between the groups inhaled the leaded gasoline and the control. The GSH content was lower in both the leaded and unleaded gasoline groups than the control group, but GSH in the unleaded group was higher than in the leaded group. The unleaded gasoline exposed group exhibited a significant decrease in superoxide dismutase activity in comparison with either the leaded gasoline or the control groups.
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Ive behaviour in male rats.Parameter GROUP Tooth chattering Control Leaded gasoline Unleaded gasoline 1.2 ?0.33 3.7 ?0.63 a* 4 ?0.87 a* Number of aggression events Threat posture 1.1 ?0.31 3.9 ?0.43 a** 3.6 ?0.87 a* Leaping and biting 0.9 ?0.35 3.7 ?0.58 a** 3.4 ?0.70 a* Boxing position 0.8 ?0.25 2.7 ?0.47 a* 3.2 ?0.74 a**Values are expressed as means ?SE a: significantly different from the contro
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Athione S -transferase activity, and lipid peroxidation was observed in liver and brain. Exposure to toluene, one of the gasoline constituents, both in vivo and in vitro, leads to reactive oxygen species formation in many tissues including brain tissue [36-38]. The study of Calder -Guzm et al [39] revealed that the aldehydes resulting from the oxidation of the methyl groups in the aromatic compou
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Mor microenvironment and its role in promoting tumor growth. Oncogene. 2008;27(45):5904?2. 52. Zamarron BF, Chen W. Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci. 2011;7(5):651?. 53. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646?4. 54. Joven J, Guirro M, Marine-Casado R, Rodriguez-Gallego E, Menendez JA.
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Ial indicate that Na+, K+-ATPase activity and total protein content in the leaded or unleaded gasoline groups were lower than those of the control group. The inhibition of the plasma membrane Na+, K+-ATPase might have been attributed to a direct effect of the solvents and alcohols in the gasoline on the membrane causing dissolving the its bilayers. The most outstanding are toluene (highly lipophyl